By F. M. Matschinsky (Editor), M. A. Magnuson (Editor)
The glucose-phosphorylating enzyme glucokinase (also referred to as hexokinase IV) performs a preeminent function as a glucose sensor and regulatory metabolic enzyme. the consequences of this principal place of glucokinase for the knowledge and remedy of diabetes mellitus are a ways attaining. This booklet addresses the molecular and human genetic, in addition to the physiological-chemical and pharmacological facets of the position glucokinase performs in glucose homeostasis and ailments of glucose metabolism, and the way the enzyme serves because the drug aim for the remedy of diabetes mellitus. the gathering of assays through a staff of the world over well known authors contains easy technology chapters facing the enzymology, constitution and the kinetics of hexokinases, essays describing the biochemical genetics of glucokinase-linked hypo- and hyperglycemia syndromes, and papers that debate the varied roles of the enzyme in quite a few tissues.
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