This quantity surveys the chemistry and heterocyclic syntheses of aminomethylenemalonates and their cyclic sters. Early stories during this box in simple terms touched on convinced points of the comparable chemistry. this can be the 1st in-depth systematic remedy of the topic. the fabric is of specific significance in medicinal chemistry as derivatives of aminomethylene malonates are key intermediates within the synthesis of antimalarial brokers. The literature reviewed has resulted in the invention of nalidixic acid and its derivatives, norfloxacin and ciprofloxacin, in addition to the recent quinolones which are energetic opposed to AIDS-related Legionella spp.
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